Obesity and High Blood Pressure Directly Cause Dementia, Study Finds
A groundbreaking study reveals obesity and hypertension are not merely risk factors for dementiaāthey are direct causes, opening new avenues for prevention.
Researchers used a method called Mendelian randomization to determine that high BMI and high blood pressure are direct causes of dementia. This technique leverages genetic variants as natural experiments, allowing scientists to infer causality without the bias of lifestyle or environmental factors.
By analyzing these genetic proxies, the study avoided confounding variables that often cloud observational research.
Vascular-related dementia emerged as the primary mechanism linking obesity and hypertension to cognitive decline. This form of dementia results from damage to blood vessels in the brain, which can be exacerbated by conditions like high blood pressure and excess weight.
The findings suggest that interventions targeting weight loss before cognitive symptoms appear could significantly reduce the risk of this specific dementia type.
Dr. Ruth Frikke-Schmidt said:
"In this study, we found high body mass index (BMI) and high blood pressure are direct causes of dementia."
Dr. Frikke-Schmidt added:
"Weight-loss medication has recently been tested for halting cognitive decline in early phases of Alzheimer's disease, but with no beneficial effect."
The study highlights the importance of early intervention. Public health strategies focusing on weight management and blood pressure control may offer a previously untapped opportunity to prevent dementia.
However, the researchers caution that Mendelian randomization relies on assumptions about genetic variant effects and may not fully capture the biological complexity of dementia development.
No independent expert commentary was included in the source.
ā ļø LEGAL DISCLAIMER: It is for informational purposes only. It never substitutes for professional medical advice, diagnosis, or treatment. Always consult your doctor regarding any questions about your health.
