Insulin Levels in Midlife Linked to Menopausal Symptom Timing and Duration

A new study suggests that women's insulin levels in their late 40s could predict the timing and severity of menopausal hot flashes—a finding that may reshape how these symptoms are managed.

Researchers from the University of Victoria analyzed data from the Study of Women's Health Across the Nation (SWAN), tracking 42–52-year-old women over 10 years.

They found that higher insulin levels at age 47 correlated with earlier onset and prolonged duration of hot flashes and night sweats. This association remained significant even after adjusting for BMI and other metabolic factors.

Faria Athar noted:

"Higher insulin at age 47 was also associated with longer durations of hot flashes and cold sweats, and a rise in testosterone levels across the menopausal transition."

Nicole Templeman explained the rationale:

"Given that insulin may be elevated in the early stages of metabolic disorders, we decided to investigate whether insulin levels prior to menopause might inform the incidence and severity of menopause symptoms."

The study does not establish causation and provides no clinical guidance for managing symptoms.

Findings highlight a correlation between midlife metabolic profiles and menopausal experiences, but further research is needed to explore actionable interventions.

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