FDA Bans Compounded GLP-1s Amid Weight Loss Drug Risks

While compounded GLP-1 weight loss drugs are now illegal to produce, their illegal availability poses a health risk as people seek quick solutions for 2026 resolutions.

The U.S. Food and Drug Administration (FDA) banned the production of compounded GLP-1 receptor agonists in 2025 after semaglutide and tirzepatide shortages were resolved.

These compounded versions—custom-mixed formulations of weight loss drugs—lack the rigorous safety and efficacy testing required for FDA-approved medications. Despite the ban, companies continue producing and distributing them, creating a gray market for unregulated treatments.

Dr. Dan Bessesen, an endocrinologist, emphasized the ethical concerns: "Your doctor has a responsibility to do what's best for you—not make money off you. The goals may be different for companies selling compounded obesity medications."

The FDA warns that compounded GLP-1s carry risks of incorrect dosages, contamination, or harmful additives.

Obesity is now recognized as a chronic metabolic condition, not a lifestyle choice, yet compounded drugs bypass clinical oversight. Public health officials urge individuals to consult physicians rather than purchase these medications online.

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