CKM Syndrome Links Heart, Kidney, and Metabolic Risks in 90% of U.S. Adults

A newly defined condition connecting heart, kidney, and metabolic disorders may silently impact nearly every American adult, yet remains virtually unknown to the public.

Nearly 90% of U.S. adults have at least one risk factor for cardiovascular-kidney-metabolic (CKM) syndrome, which combines heart disease, kidney disease, diabetes, and obesity into a single high-risk health cycle. However, only 12% of U.S. adults had heard of CKM syndrome, despite its prevalence.

The American Heart Association conducted a survey of 4,000 U.S. adults (August 2025) to assess awareness. Data were weighted to reflect U.S. population proportions.

The survey revealed significant misconceptions: 68% believed conditions should be managed “one at a time,” while 42% thought a healthy heart was unaffected by other systems.

Dr. Eduardo Sanchez said:

"We want people to know that it's really common to have heart, kidney and metabolic risk factors at the same time. It is reassuring that once the CKM connection was defined nearly three-quarters of those responding understood that it was important and wanted to learn more."

Dr. Sanchez added:

"The heart, kidney and metabolic systems are connected and, as such, should be treated in a coordinated way."

Seventy-two percent of respondents wanted information about CKM syndrome treatment, and 71% sought details on diagnosis. In response, the American Heart Association plans to release first-ever clinical guidelines for CKM syndrome in early 2026.

Public health action includes launching educational tools and an online resource hub to promote interdisciplinary care for CKM health.

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