Chemotherapy's Gut Impact May Hinder Cancer Spread Through Microbial Metabolite

Chemotherapy’s gut-damaging side effects may hold a secret weapon against cancer metastasis, as new research reveals a microbial signal that reprograms the immune system.

Chemotherapy-induced gut damage alters microbiota composition, increasing production of indole-3-propionic acid (IPA), a microbial metabolite derived from tryptophan.

IPA travels to the bone marrow, reducing immunosuppressive monocyte production and enhancing anti-cancer immune defenses. In colorectal cancer patients, higher post-chemotherapy IPA levels correlate with lower monocyte counts and improved survival outcomes.

Ludivine Bersier said:

"We were surprised by how a side effect often seen as collateral damage of chemotherapy can trigger such a structured systemic response..."

Tatiana Petrova said:

"This work shows that the effects of chemotherapy extend far beyond the tumor itself..."

The study, published in Nature Communications (2025), was a collaboration between the University of Lausanne and Geneva University Hospitals. Researchers caution that no clinical guidance is provided, and further research is needed before changing practice.

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